Back to search

Article

Natural Glycoside Salidroside Ameliorates Orthopedic Surgery-Induced Cognitive Dysfunction Through Activating Adenosine 5‘-Monophosphate-Activated Protein Kinase Signaling in Mice

2021-08-03

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Perioperative neurocognitive disorders (PND) are the most common postoperative complications with few therapeutic options. Salidroside, a plant-derived compound, has gained increased attention as treatment for various neurological diseases and particularly modifier of microglia-mediated neuroinflammation. However, the effect of salidroside on orthopedic surgery-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f3100b7f-558b-504d-8bed-ef3c9815a4ab
DOI
10.21203/rs.3.rs-745010/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Natural Glycoside Salidroside Ameliorates Orthopedic Surgery-Induced Cognitive Dysfunction Through Activating Adenosine 5‘-Monophosphate-Activated Protein Kinase Signaling in MiceDOI 10.21203/rs.3.rs-745010/v1
Inflammatory signalling in postoperative cognitive dysfunctionsSemantic proximity
Glibenclamide Directly Prevents Neuroinflammation by Targeting SUR1-TRPM4-Mediated NLRP3 Inflammasome Activation in MicrogliaSemantic proximity
Germacrone attenuates memory impairment, hippocampal inflammation, and neurological deficits induced by Lipopolysaccharide in miceSemantic proximity
Transcriptome Profile in Hippocampus During Acute Inflammatory Response to Surgery: Toward Early Stage of PNDSemantic proximity
The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disordersSemantic proximity
Compound porcine cerebroside and ganglioside injections improved anxiety and cognitive dysfunction through the NF-κB pathway in cerebral ischemia-reperfusion injurySemantic proximity
Brain Network Homeostasis and Plasticity of Salidroside for Achieving Neuroprotection and Treating Psychiatric Sequelae Stemming from StressSemantic proximity
Whole‐transcriptome sequencing identifies neuroinflammation, metabolism and blood–brain barrier related processes in the hippocampus of aged mice during perioperative periodSemantic proximity
Guizhi Fuling capsule relieves memory deficits by inhibition of microglial neuroinflammation through blocking JAK2/STAT3 pathway in presenilin1/2 conditional double knockout miceSemantic proximity
Asperosaponin VI ameliorates the CMS-induced depressive-like behaviors by inducing a neuroprotective microglial phenotype in hippocampus via PPAR-γ pathway.Semantic proximity
The effect of esketamine on perioperative neurocognitive dysfunction in elderly patients who underwent gastrointestinal tumor surgery: a randomized double-blind controlled studySemantic proximity
Activation of Liver X receptors alleviates neuropathic pain-induced cognitive dysfunction by modulating PI3K/AKT-mediated microglia polarizationSemantic proximity
Select a neighboring publication to make it the new centre.