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Article

Monosodium iodoacetate-induced joint pain is associated with increased phosphorylation of mitogen activated protein kinases in the rat spinal cord.

Molecular pain - 20 May 2011

Lee Younglim, Pai Madhavi, Brederson Jill-Desiree, Wilcox Denise, Hsieh Gin, Jarvis Michael F, Bitner Robert S

Abstract excerpt

BACKGROUND: Intra-articular injection of monosodium iodoacetate (MIA) in the knee joint of rats disrupts chondrocyte metabolism resulting in cartilage degeneration and subsequent nociceptive behavior that has been described as a model of osteoarthritis (OA) pain. Central sensitization through activation of mitogen activated protein kinases (MAPKs) is recognized as a pathogenic mechanism in chronic pain. In the...

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Source

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Identifiers

PMID: 21599960
DOI: 10.1186/1744-8069-7-39
PMCID: PMC3120677

Genes

MIA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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