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Article

Acute inhibition of signalling phenotype of spinal GABAergic neurons by tumour necrosis factor-alpha.

The Journal of physiology - 15 Sept 2011

Zhang Haijun, Dougherty Patrick M

Abstract excerpt

Spinal application of TNFα induces both allodynia and hyperalgesia, and at least part of the pronociceptive effects of TNFα have been suggested as due to the impaired function of spinal inhibitory neurons (disinhibition). The present study explores the effects of TNFα on the signalling phenotype of spinal GABAergic neurons identified in transgenic mice expressing green fluorescent protein at the glutamic acid...

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Identifiers

PMID: 21788348
DOI: 10.1113/jphysiol.2011.215301
PMCID: PMC3208221

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