Article
Palmitoylethanolamide reduces formalin-induced neuropathic-like behaviour through spinal glial/microglial phenotypical changes in mice.
CNS & neurological disorders drug targets - 1 Feb 2013
Luongo Livio, Guida Francesca, Boccella Serena, Bellini Giulia, Gatta Luisa, Rossi Francesca, de Novellis Vito, Maione Sabatino
Abstract excerpt
Palmitoylethanolamide (PEA) is an endogenous cannabinoid-like compound in the central nervous system, which can modulate several functions in different pathological states, such as inflammation and pain response. We have here investigated the effect of PEA (5-10 mg/kg, intraperitoneally) on mechanical allodynia and thermal hyperalgesia 3 and 7 days following peripheral injection of formalin. Formalin induced a...
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