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Article

HIV-1 Vpr suppresses the cytomegalovirus promoter in a CRL4(DCAF1) E3 ligase independent manner.

Biochemical and biophysical research communications - 3 Apr 2015

Liu Xianjun, Guo Haoran, Wang Hong, Markham Richard, Wei Wei, Yu Xiao-Fang

Abstract excerpt

Although the Vpr protein of human immunodeficiency virus type 1 (HIV-1) has been shown to act as a transcriptional activator of the HIV-1 LTR and certain host genes, the current study demonstrates that it can also function as a potent inhibitor of the cytomegalovirus (CMV) promoter. Previous studies have shown that the cell cycle arrest and apoptotic functions of Vpr required recruitment of the CRL4(DCAF1) E3...

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Share to Cytomegalovirus
Share to DNA Glycosylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HeLa Cells

Share to HIV Long Terminal Repeat

Share to Host-Pathogen Interactions

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Share to Ubiquitin-Protein Ligases

Share to vpr Gene Products, Human Immunodeficiency Virus

Source

Identifiers

PMID: 25704090
DOI: 10.1016/j.bbrc.2015.02.060

Genes

DCAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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