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Article

Dual Functionality of HIV-1 Vif in APOBEC3 Counteraction and Cell Cycle Arrest

12 Jan 2021

Abstract excerpt

Accessory proteins are a key feature that distinguishes primate immunodeficiency viruses such as human immunodeficiency virus type I (HIV-1) from other retroviruses. A prime example is the virion infectivity factor, Vif, which hijacks a cellular co-transcription factor (CBF-β) to recruit a ubiquitin ligase complex (CRL5) to bind and degrade antiviral APOBEC3 enzymes including APOBEC3D (A3D), APOBEC3F (A3F),...

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PMID: 33510734
DOI: 10.3389/fmicb.2020.622012

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