Article
Molecular insight into how HIV-1 Vpr protein impairs cell growth through two genetically distinct pathways.
The Journal of biological chemistry - 8 Jul 2011
Maudet Claire, Bertrand Matthieu, Le Rouzic Erwann, Lahouassa Hichem, Ayinde Diana, Nisole Sébastien, Goujon Caroline, Cimarelli Andrea, Margottin-Goguet Florence, Transy Catherine
Abstract excerpt
Vpr, a small HIV auxiliary protein, hijacks the CUL4 ubiquitin ligase through DCAF1 to inactivate an unknown cellular target, leading to cell cycle arrest at the G(2) phase and cell death. Here we first sought to delineate the Vpr determinants involved in the binding to DCAF1 and to the target. On the one hand, the three α-helices of Vpr are necessary and sufficient for binding to DCAF1; on the other hand,...
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