Article
Dual islet transplantation modeling of the instant blood-mediated inflammatory reaction.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 May 2015
Martin B M, Samy K P, Lowe M C, Thompson P W, Cano J, Farris A B, Song M, Dove C R, Leopardi F V, Strobert E A, Jenkins J B, Collins B H, Larsen C P, Kirk A D
Abstract excerpt
Islet xenotransplantation is a potential treatment for diabetes without the limitations of tissue availability. Although successful experimentally, early islet loss remains substantial and attributed to an instant blood-mediated inflammatory reaction (IBMIR). This syndrome of islet destruction has been incompletely defined and characterization in pig-to-primate models has been hampered by logistical and...
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