Article

Engineering sialylation in pigs: A promising strategy for overcoming xenograft rejection and revolutionizing organ transplantation

2025-05-04

Abstract excerpt

The organ shortage crisis leaves over 100,000 people waiting for transplants, causing 6,000 deaths annually. To address this, pigs are being explored as potential donors. Despite advances like the FDA-approved GalSafe pig, immunological challenges remain. Key issues include strong antibody, innate, and cellular immune responses, along with coagulation problems due to differences in glycosides and sialic acid linka...

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Identifiers and source

Literature Corpus work: 9b422aba-336b-5367-95cd-e538bdaf2ee7
DOI: 10.1101/2025.04.30.651299

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