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Pig-to-Monkey Islet Xenotransplantation Using Multi-Transgenic Pigs

12 Sept 2014

Abstract excerpt

The generation of pigs with genetic modifications has significantly advanced the field of xenotransplantation. New genetically engineered pigs were produced on an α1,3-galactosyltransferase gene-knockout background with ubiquitous expression of human CD46, with islet beta cell-specific expression of human tissue factor pathway inhibitor and/or human CD39 and/or porcine CTLA4-lg. Isolated islets from pigs with 3,...

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PMID: 25220221
DOI: 10.1111/ajt.12868

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