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Article

Controlling coagulation dysregulation in xenotransplantation

4 Feb 2011

Abstract excerpt

PURPOSE OF REVIEW: Deletion of the α1,3-galactosyltransferase (GalT) gene in pigs has removed a major xenoantigen but has not eliminated the problem of dysregulated coagulation and vascular injury. Rejecting GalT knockout organ xenografts almost invariably show evidence of thrombosis and platelet sequestration, and primate recipients frequently develop consumptive coagulopathy. This review examines recent...

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PMID: 21415824
DOI: 10.1097/mot.0b013e3283446c65

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