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Progress in xenotransplantation following the introduction of gene-knockout technology

2 Nov 2006

Abstract excerpt

The production of alpha1,3-galactosyltransferase gene-knockout (GT-KO) pigs has overcome the barrier of preformed anti-Galalpha1,3Gal (Gal) antibodies that has inhibited progress in pig-to-primate organ xenotransplantation for many years. Survival of GT-KO pig organs in nonhuman primates is currently limited by the development of a thrombotic microangiopathy that results in increasing ischemic injury of the...

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PMID: 17239018
DOI: 10.1111/j.1432-2277.2006.00398.x

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