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Article

IDH mutation status and role of WHO grade and mitotic index in overall survival in grade II-III diffuse gliomas.

Acta neuropathologica - 1 Apr 2015

Olar Adriana, Wani Khalida M, Alfaro-Munoz Kristin D, Heathcock Lindsey E, van Thuijl Hinke F, Gilbert Mark R, Armstrong Terri S, Sulman Erik P, Cahill Daniel P, Vera-Bolanos Elizabeth, Yuan Ying, Reijneveld Jaap C, Ylstra Bauke, Wesseling Pieter, Aldape Kenneth D

Abstract excerpt

Diffuse gliomas are up till now graded based upon morphology. Recent findings indicate that isocitrate dehydrogenase (IDH) mutation status defines biologically distinct groups of tumors. The role of tumor grade and mitotic index in patient outcome has not been evaluated following stratification by IDH mutation status. To address this, we interrogated 558 WHO grade II-III diffuse gliomas for IDH1/2 mutations and...

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Source

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Identifiers

PMID: 25701198
DOI: 10.1007/s00401-015-1398-z
PMCID: PMC4369189

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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