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Article

IDH mutant diffuse and anaplastic astrocytomas have similar age at presentation and little difference in survival: a grading problem for WHO.

Acta neuropathologica - 1 Jun 2015

Reuss David E, Mamatjan Yasin, Schrimpf Daniel, Capper David, Hovestadt Volker, Kratz Annekathrin, Sahm Felix, Koelsche Christian, Korshunov Andrey, Olar Adriana, Hartmann Christian, Reijneveld Jaap C, Wesseling Pieter, Unterberg Andreas, Platten Michael, Wick Wolfgang, Herold-Mende Christel, Aldape Kenneth, von Deimling Andreas

Abstract excerpt

The WHO 2007 classification of tumors of the CNS distinguishes between diffuse astrocytoma WHO grade II (A II(WHO2007)) and anaplastic astrocytoma WHO grade III (AA III(WHO2007)). Patients with A II(WHO2007) are significantly younger and survive significantly longer than those with AA III(WHO2007). So far, classification and grading relies on morphological grounds only and does not yet take into account IDH...

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Identifiers

PMID: 25962792
DOI: 10.1007/s00401-015-1438-8
PMCID: PMC4500039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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