Article
Tailored therapy in diffuse gliomas: using molecular classifiers to optimize clinical management.
Oncology (Williston Park, N.Y.) - 1 Jun 2013
Taylor Jennie W, Chi Andrew S, Cahill Daniel P
Abstract excerpt
Diffuse gliomas are the most common primary malignant brain tumors in adults and continue to be almost universally fatal. Nevertheless, a striking variability in outcome has long been observed, with a subset of patients having prolonged survival. Recent molecular discoveries have provided new insights into gliomagenesis and have enhanced clinical subclassification of gliomas. Mutations in the isocitrate...
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