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Article

PI3 kinase mutations and mutational load as poor prognostic markers in diffuse glioma patients.

Acta neuropathologica communications - 23 Dec 2015

Draaisma Kaspar, Wijnenga Maarten M J, Weenink Bas, Gao Ya, Smid Marcel, Robe P, van den Bent Martin J, French Pim J

Abstract excerpt

INTRODUCTION: Recent advances in molecular diagnostics allow diffuse gliomas to be classified based on their genetic changes into distinct prognostic subtypes. However, a systematic analysis of all molecular markers has thus far not been performed; most classification schemes use a predefined and select set of genes/molecular markers. Here, we have analysed the TCGA dataset (combined glioblastoma (GBM) and lower...

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Source

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Identifiers

PMID: 26699864
DOI: 10.1186/s40478-015-0265-4
PMCID: PMC4690424

Genes

ATRX
IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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