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Article

Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention.

Science (New York, N.Y.) - 24 Mar 2017

Tomasetti Cristian, Li Lu, Vogelstein Bert

Abstract excerpt

Cancers are caused by mutations that may be inherited, induced by environmental factors, or result from DNA replication errors (R). We studied the relationship between the number of normal stem cell divisions and the risk of 17 cancer types in 69 countries throughout the world. The data revealed a strong correlation (median = 0.80) between cancer incidence and normal stem cell divisions in all countries,...

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Identifiers

PMID: 28336671
DOI: 10.1126/science.aaf9011
PMCID: PMC5852673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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