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Article

BRAF V600E mutation analysis simplifies the testing algorithm for Lynch syndrome.

American journal of clinical pathology - 1 Aug 2013

Jin Ming, Hampel Heather, Zhou Xiaoping, Schunemann Lisa, Yearsley Martha, Frankel Wendy L

Abstract excerpt

OBJECTIVES: To evaluate our experience of adding reflex BRAF mutation analysis following mismatch repair (MMR) protein staining in the test algorithm for Lynch syndrome (LS), the most common inherited predisposition to colorectal cancer (CRC). METHODS: Since January 1, 2009, BRAF V600E mutation analysis has been performed at our institution for all newly diagnosed CRCs with absent MLH1 and PMS2 proteins. RESULTS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23897252
DOI: 10.1309/AJCPB9FOVH1HGKFR

Genes

BRAF
MLH1
PMS2

Variants

Provenance

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