Article

<i>BRAF</i>mutation testing of MSI CRCs in Lynch syndrome diagnostics: performance and efficiency according to patient’s age

2019-10-16

Abstract excerpt

<h4>Background and aims</h4> BRAF V600E mutations have been reported to be associated with sporadic microsatellite-unstable (MSI) colorectal cancer (CRC), while rarely detected in CRCs of Lynch syndrome (LS) patients. Therefore, current international diagnostic guidelines recommend somatic BRAF mutation testing in MLH1-deficient MSI CRC patients to exclude LS. As sporadic BRAF -mutant MSI CRC is a disease of the e...

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Literature Corpus work: 9277e020-92cd-5162-86ac-78238ce0e4f1
DOI: 10.1101/19009274

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