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Article

Impact of universal immunohistochemistry on Lynch syndrome diagnosis in an Australian colorectal cancer cohort

23 Jan 2019

Abstract excerpt

BACKGROUND: Current guidelines recommend a step-wise screening algorithm for all colorectal carcinomas (CRC) to identify patients with Lynch syndrome (LS). AIM: To describe the frequencies of mismatch repair deficiency (dMMR), BRAFV600E mutations and MLH1 methylation in resected CRC, and evaluate the impact of universal screening on LS detection. METHODS: Retrospectively, 1171 consecutive cases of resected CRC...

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PMID: 30667141
DOI: 10.1111/imj.14230

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