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Article

Somatic STK11 and concomitant STK11/KRAS mutational frequency in stage IV lung adenocarcinoma adrenal metastases.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Mar 2015

Gleeson Ferga C, Kipp Benjamin R, Levy Michael J, Voss Jesse S, Campion Michael B, Minot Douglas M, Tu Zheng J, Klee Eric W, Lazaridis Konstantinos N, Kerr Sarah E

Abstract excerpt

Somatic serine/threonine kinase 11 (STK11) also known as liver kinase B1 (LKB1) is a tumor suppressor gene and ranks as the third most frequently mutated gene in lung adenocarcinoma. However, current molecular testing guidelines recommend evaluating for epidermal growth factor receptor mutations and ALK fusions to guide therapy in all patients with advanced stage adenocarcinoma, regardless of gender, race, or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25695224
DOI: 10.1097/JTO.0000000000000391

Genes

STK11
KRAS
ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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