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Article

A Sensitive NanoString-Based Assay to Score STK11 (LKB1) Pathway Disruption in Lung Adenocarcinoma.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jun 2016

Chen Lu, Engel Brienne E, Welsh Eric A, Yoder Sean J, Brantley Stephen G, Chen Dung-Tsa, Beg Amer A, Cao Chunxia, Kaye Frederic J, Haura Eric B, Schabath Matthew B, Cress W Douglas

Abstract excerpt

INTRODUCTION: Serine/threonine kinase 11 gene (STK11), better known as liver kinase β1, is a tumor suppressor that is commonly mutated in lung adenocarcinoma (LUAD). Previous work has shown that mutational inactivation of the STK11 pathway may serve as a predictive biomarker for cancer treatments, including phenformin and cyclooxygenase-2 inhibition. Although immunohistochemical (IHC) staining and diagnostic...

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Identifiers

PMID: 26917230
DOI: 10.1016/j.jtho.2016.02.009
PMCID: PMC4877210

Genes

STK11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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