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Comparative bioinformatic analysis of KRAS, STK11 and KEAP1 (co-)mutations in non-small cell lung cancer with a special focus on KRAS G12C.

Lung cancer (Amsterdam, Netherlands) - 1 Oct 2023

Boeschen Myriam, Kuhn Christina Katharina, Wirtz Hubert, Seyfarth Hans-Jürgen, Frille Armin, Lordick Florian, Hacker Ulrich T, Obeck Ulrike, Stiller Mathias, Bläker Hendrik, von Laffert Maximilian

Abstract excerpt

OBJECTIVES: Mutations in STK11 (STK11MUT) and KEAP1 (KEAP1MUT) occur frequently in non-small cell lung cancer (NSCLC) and are often co-mutated with KRAS. Several studies linked the co-occurrence of KRASMUT + STK11MUT, as well as KRASMUT + KEAP1MUT to reduced response to immune checkpoint inhibitors (ICI) and even a negative impact on survival. Data focusing STK11 + KEAP1 co-mutations or the triple mutation...

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PMID: 37699269
DOI: 10.1016/j.lungcan.2023.107361

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