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Article

CoA protects against the deleterious effects of caloric overload in Drosophila.

Journal of lipid research - 1 Mar 2016

Palanker Musselman Laura, Fink Jill L, Baranski Thomas J

Abstract excerpt

We developed a Drosophila model of T2D in which high sugar (HS) feeding leads to insulin resistance. In this model, adipose TG storage is protective against fatty acid toxicity and diabetes. Initial biochemical and gene expression studies suggested that deficiency in CoA might underlie reduced TG synthesis in animals during chronic HS feeding. Focusing on the Drosophila fat body (FB), which is specialized for TG...

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Identifiers

PMID: 26805007
DOI: 10.1194/jlr.M062976
PMCID: PMC4766987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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