Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional Inactivation of Drosophila GCK Orthologs Causes Genomic Instability and Oxidative Stress in a Fly Model of MODY-2.

International journal of molecular sciences - 18 Jan 2021

Mascolo Elisa, Liguori Francesco, Stufera Mecarelli Lorenzo, Amoroso Noemi, Merigliano Chiara, Amadio Susanna, Volonté Cinzia, Contestabile Roberto, Tramonti Angela, Vernì Fiammetta

Abstract excerpt

Maturity-onset diabetes of the young (MODY) type 2 is caused by heterozygous inactivating mutations in the gene encoding glucokinase (GCK), a pivotal enzyme for glucose homeostasis. In the pancreas GCK regulates insulin secretion, while in the liver it promotes glucose utilization and storage. We showed that silencing the Drosophila GCK orthologs Hex-A and Hex-C results in a MODY-2-like hyperglycemia. Targeted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Glucose
Share to Genomic Instability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucokinase

Share to Glycation End Products, Advanced

Share to Hyperglycemia

Share to Oxidative Stress

Share to Vitamin B 6

Source

Open in PubMed Open full text

Identifiers

PMID: 33477627
DOI: 10.3390/ijms22020918
PMCID: PMC7831483

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional Inactivation of Drosophila GCK Orthologs Causes Genomic Instability and Oxidative Stress in a Fly Model of MODY-2.PMID 33477627Read ↗

Glucokinase (GCK) in diabetes: from molecular mechanisms to disease pathogenesis.Semantic proximity Read ↗

Sugar and chromosome stability: clastogenic effects of sugars in vitamin B6-deficient cells.Semantic proximity Read ↗

Glucokinase Inactivation Ameliorates Lipid Accumulation and Exerts Favorable Effects on Lipid Metabolism in Hepatocytes.Semantic proximity Read ↗

Genotype-phenotype discrepancy among family members carrying a novel glucokinase mutation: insights into the interplay of GCK-MODY and insulin resistanceSemantic proximity Read ↗

A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program.Semantic proximity Read ↗

Fatty acid synthase cooperates with glyoxalase 1 to protect against sugar toxicity.Semantic proximity Read ↗

Enhanced oxidative stress and endocrine pancreas alterations are linked to a novel glucokinase missense mutation in ENU-derived Munich Gck(D217V) mutants.Semantic proximity Read ↗

Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism.Semantic proximity Read ↗

Sex-dependent additive effects of dorzagliatin and incretin on insulin secretion in a novel mouse model of <i>GCK</i> -MODYSemantic proximity Read ↗

Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects.Semantic proximity Read ↗

Generation of two human iPSC lines from patients with maturity-onset diabetes of the young type 2 (MODY2) and permanent neonatal diabetes due to mutations in the GCK gene.Semantic proximity Read ↗

Drosophila Pyruvate Kinase Links Metabolic State with Circadian Output via TARANIS and PDFSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.