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Article

Analysis of Novel Interactions between Components of the Selenocysteine Biosynthesis Pathway, SEPHS1, SEPHS2, SEPSECS, and SECp43.

Biochemistry - 2 May 2017

Oudouhou Flore, Casu Bastien, Dopgwa Puemi Arnold Steve, Sygusch Jurgen, Baron Christian

Abstract excerpt

In mammalian cells, the incorporation of the 21st amino acid, selenocysteine, into proteins is guided by the Sec machinery. The function of this protein complex requires several protein-protein and protein-RNA interactions, leading to the incorporation of selenocysteine at UGA codons. It is guided by stem-loop structures localized in the 3' untranslated regions of the selenoprotein-encoding genes. Here, we...

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Source

Identifiers

PMID: 28414460
DOI: 10.1021/acs.biochem.6b01116

Genes

SEPHS1
SEPHS2
SEPSECS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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