Article

Schizophrenia, variability, and the Anna Karenina principle

2025-10-01

Abstract excerpt

In neuroimaging studies of people with schizophrenia there is often higher within group variance in the patient group compared to the control group. This is counterintuitive – why would a subset of people selected because they all have the same disease be more varied than the general population? We used simulated data and real neuroimaging data to identify a potential cause of elevated variance in populations of p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3d5d12e2-1113-5d9d-b3da-8a241f377f7c
DOI: 10.1101/2025.09.30.679570

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Schizophrenia, variability, and the Anna Karenina principleDOI 10.1101/2025.09.30.679570Read

Linking Brain Entropy to Molecular and Cellular Architecture in PsychosisSemantic proximity Read

Dissecting Heterogeneity in Functional Network Connectivity Aberrations in Antipsychotic Medication-Naïve First Episode Psychosis Patients – A Normative Modeling StudySemantic proximity Read

Brain heterogeneity in 1,792 individuals with schizophrenia: effects of illness stage, sites of origin and pathophysiologySemantic proximity Read

Schizophrenia: a systemic disorder.Semantic proximity Read

Novel network approaches for the interrogation of large data sets with relevance to schizophreniaSemantic proximity Read

Variability and Magnitude of Brain Glutamate Levels in Schizophrenia: A Meta And Mega-AnalysisSemantic proximity Read

When Randomness Becomes Rigid: Dynamic Connectivity Entropy and Symptom-Linked Network Dysfunction in SchizophreniaSemantic proximity Read

Replicating extensive brain structural heterogeneity in individuals with schizophrenia and bipolar disorderSemantic proximity Read

Replicating extensive brain structural heterogeneity in individuals with schizophrenia and bipolar disorderSemantic proximity Read

A continuum of psychosis, one human gene, and not much else — the case for homogeneitySemantic proximity Read

Schizophrenia polygenic risk scores, urbanicity and treatment-resistant schizophreniaSemantic proximity Read

A Dynamic Entropy Approach Reveals Reduced Functional Network Connectivity Trajectory Complexity in SchizophreniaSemantic proximity Read