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Article

Simulating the Effects of Common Comedications and Genotypes on Alzheimer's Cognitive Trajectory Using a Quantitative Systems Pharmacology Approach.

Journal of Alzheimer's disease : JAD - 1 Jan 2020

Geerts Hugo, Spiros Athan

Abstract excerpt

BACKGROUND: Many Alzheimer's disease patients in clinical practice are on polypharmacy for treatment of comorbidities. OBJECTIVE: While pharmacokinetic interactions between drugs have been relatively well established with corresponding treatment guidelines, many medications and common genotype variants also affect central brain circuits involved in cognitive trajectory, leading to complex pharmacodynamic...

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PMID: 33016912
DOI: 10.3233/JAD-200688

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