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Article

NusA interaction with the α subunit of E. coli RNA polymerase is via the UP element site and releases autoinhibition.

Structure (London, England : 1993) - 13 Jul 2011

Schweimer Kristian, Prasch Stefan, Sujatha Pagadala Santhanam, Bubunenko Mikhail, Gottesman Max E, Rösch Paul

Abstract excerpt

Elongating Escherichia coli RNAP is modulated by NusA protein. The C-terminal domain (CTD) of the RNAP α subunit (αCTD) interacts with the acidic CTD 2 (AR2) of NusA, releasing the autoinhibitory blockade of the NusA S1-KH1-KH2 motif and allowing NusA to bind nascent nut spacer RNA. We determined the solution conformation of the AR2:αCTD complex. The αCTD residues that interface with AR2 are identical to those...

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Identifiers

PMID: 21742261
DOI: 10.1016/j.str.2011.03.024
PMCID: PMC3134791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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