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Article

Molecular recognition of PTS-1 cargo proteins by Pex5p: implications for protein mistargeting in primary hyperoxaluria.

Biomolecules - 13 Feb 2015

Mesa-Torres Noel, Tomic Nenad, Albert Armando, Salido Eduardo, Pey Angel L

Abstract excerpt

Peroxisomal biogenesis and function critically depends on the import of cytosolic proteins carrying a PTS1 sequence into this organelle upon interaction with the peroxin Pex5p. Recent structural studies have provided important insights into the molecular recognition of cargo proteins by Pex5p. Peroxisomal import is a key feature in the pathogenesis of primary hyperoxaluria type 1 (PH1), where alanine:glyoxylate...

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Source

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Identifiers

PMID: 25689234
DOI: 10.3390/biom5010121
PMCID: PMC4384115

Genes

AGT
PTS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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