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Article

The molecular basis of alanine: glyoxylate aminotransferase mistargeting: the most common single cause of primary hyperoxaluria type 1.

Journal of nephrology - 1 Jan 2000

Danpure C J

Abstract excerpt

The autosomal recessive disease primary hyperoxaluria type 1 (PH1) is caused by a deficiency of the liver-specific intermediary metabolic enzyme alanine:glyoxylate aminotransferase (AGT). In a third of all Caucasian PH1 patients, disease in caused by an unparalleled intracellular phenomenon in which AGT is mistargeted from one group of intracellular organelles (the peroxisomes) to another (the mitochondria) where...

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Source

Identifiers

PMID: 9604801

Genes

AGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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