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Article

The role of protein denaturation energetics and molecular chaperones in the aggregation and mistargeting of mutants causing primary hyperoxaluria type I.

PloS one - 1 Jan 2013

Mesa-Torres Noel, Fabelo-Rosa Israel, Riverol Debora, Yunta Cristina, Albert Armando, Salido Eduardo, Pey Angel L

Abstract excerpt

Primary hyperoxaluria type I (PH1) is a conformational disease which result in the loss of alanine:glyoxylate aminotransferase (AGT) function. The study of AGT has important implications for protein folding and trafficking because PH1 mutants may cause protein aggregation and mitochondrial mistargeting. We herein describe a multidisciplinary study aimed to understand the molecular basis of protein aggregation and...

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Source

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Identifiers

PMID: 24205397
DOI: 10.1371/journal.pone.0071963
PMCID: PMC3796444

Genes

AGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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