Quantitative analysis of peroxisomal targeting signal type-1 binding to wild-type and pathogenic mutants of Pex5p supports an affinity threshold for peroxisomal protein targeting.

Abstract excerpt

Peroxisomal biogenesis disorders (PBDs) are caused by mutations in 12 distinct genes that encode the components of the peroxisome assembly machinery. Three mutations in the gene encoding Pex5p, the peroxisomal targeting signal type-1 (PTS1) receptor, have been reported, each associated with a dis...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Models, Molecular
• Share to Peptides
• Share to Peroxisome-Targeting Signal 1 Receptor