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Article

Lrp4 domains differentially regulate limb/brain development and synaptic plasticity.

PloS one - 1 Jan 2015

Pohlkamp Theresa, Durakoglugil Murat, Lane-Donovan Courtney, Xian Xunde, Johnson Eric B, Hammer Robert E, Herz Joachim

Abstract excerpt

Apolipoprotein E (ApoE) genotype is the strongest predictor of Alzheimer's Disease (AD) risk. ApoE is a cholesterol transport protein that binds to members of the Low-Density Lipoprotein (LDL) Receptor family, which includes LDL Receptor Related Protein 4 (Lrp4). Lrp4, together with one of its ligands Agrin and its co-receptors Muscle Specific Kinase (MuSK) and Amyloid Precursor Protein (APP), regulates...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Limb Deformities, Congenital

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Source

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Identifiers

PMID: 25688974
DOI: 10.1371/journal.pone.0116701
PMCID: PMC4331535

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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