Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Promoter hypermethylation of TERT is associated with hepatocellular carcinoma in the Han Chinese population.

Clinics and research in hepatology and gastroenterology - 1 Oct 2015

Zhang Hong, Weng Xiaoling, Ye Junyi, He Lin, Zhou Daizhan, Liu Yun

Abstract excerpt

BACKGROUND: Upstream of the transcription start site (UTSS), hypermethylation of the telomerase reverse transcriptase (TERT) gene has been shown to be associated with tumour progression and a poor prognosis in paediatric brain tumours (Castelo-Branco 2013). It has been inferred that the UTSS region of TERT is a potentially accessible biomarker for various cancers. In this study, we aimed to explore the role of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian People
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Hepatocellular

Share to Disease Progression

Share to DNA Methylation

Share to Gene Expression Regulation, Neoplastic

Share to Liver Neoplasms

Share to Telomerase

Source

Identifiers

PMID: 25683523
DOI: 10.1016/j.clinre.2015.01.002

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Promoter hypermethylation of TERT is associated with hepatocellular carcinoma in the Han Chinese population.PMID 25683523Read ↗

The TERT promoter mutation incidence is modified by germline TERT rs2736098 and rs2736100 polymorphisms in hepatocellular carcinoma.Semantic proximity Read ↗

Clinicopathological characteristics of TERT promoter mutation and telomere length in hepatocellular carcinoma.Semantic proximity Read ↗

Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation.Semantic proximity Read ↗

DNA hypermethylation within TERT promoter upregulates TERT expression in cancerSemantic proximity Read ↗

Frequency and geographic distribution of TERT promoter mutations in primary hepatocellular carcinomaSemantic proximity Read ↗

Polymorphisms of TERT and CLPTM1L and the risk of hepatocellular carcinoma in Chinese males.Semantic proximity Read ↗

The TERT promoter SNP rs2853669 decreases E2F1 transcription factor binding and increases mortality and recurrence risks in liver cancer.Semantic proximity Read ↗

Identification of genes involved in the regulation of TERT in hepatocellular carcinomaSemantic proximity Read ↗

Association of TERT (rs2736098 and rs2736100) genetic variants with elevated risk of hepatocellular carcinoma: a retrospective case-control study.Semantic proximity Read ↗

Telomerase reverse transcriptase promoter mutations in hepatitis B virus-associated hepatocellular carcinoma.Semantic proximity Read ↗

Association of Tert Promoter Mutations With Early Recurrence in Hepatocellular Carcinoma: A Subgroup Analysis in a Vietnamese CohortSemantic proximity Read ↗

TERT promoter mutations in primary liver tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.