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Article

Peripheral neuropathy in hereditary spastic paraplegia due to spastin (SPG4) mutation--a neurophysiological study using excitability techniques.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology - 1 Jul 2012

Kumar Kishore R, Sue Carolyn M, Burke David, Ng Karl

Abstract excerpt

OBJECTIVE: To identify peripheral nerve abnormalities in hereditary spastic paraplegia (HSP) due to mutations in the spastin gene (spastic paraplegia 4, SPG4) using standard nerve conduction (NCS) and novel tests of axonal excitability. METHODS: Eleven patients with known mutations in spastin were assessed with NCS for the upper and lower limbs, and axonal excitability testing on the median nerve. RESULTS:...

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Identifiers

PMID: 22192498
DOI: 10.1016/j.clinph.2011.11.080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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