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Article

Axonal ion channel dysfunction in c9orf72 familial amyotrophic lateral sclerosis.

JAMA neurology - 1 Jan 2015

Geevasinga Nimeshan, Menon Parvathi, Howells James, Nicholson Garth A, Kiernan Matthew C, Vucic Steve

Abstract excerpt

IMPORTANCE: Abnormalities of axonal excitability characterized by upregulation of persistent sodium (Na+) conductances and reduced potassium (K+) currents have been reported in sporadic amyotrophic lateral sclerosis (SALS) phenotypes and linked to the development of clinical features such as fasciculations and neurodegeneration. OBJECTIVE: To investigate whether abnormalities of axonal ion channel function,...

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PMID: 25384182
DOI: 10.1001/jamaneurol.2014.2940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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