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Article

The role of transgenic mouse models in carcinogen identification.

22 Oct 2002

Abstract excerpt

In this article, we examine existing data on the use of transgenic mouse models for identification of human carcinogens. We focus on the three most extensively studied of these mice, Trp53+/-, Tg/AC, and RasH2, and compare their performance with the traditional 2-year rodent bioassay. Data on 99 chemicals were evaluated. Using the International Agency for Research on Cancer/Report on Carcinogens determinations...

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PMID: 12676597
DOI: 10.1289/ehp.5778

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