Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ccr4 promotes resolution of the endoplasmic reticulum stress response during host temperature adaptation in Cryptococcus neoformans.

Eukaryotic cell - 1 Jul 2011

Havel Virginia E, Wool Nathan K, Ayad David, Downey Kurtis M, Wilson Christabel F, Larsen Peter, Djordjevic Julianne T, Panepinto John C

Abstract excerpt

Adaptation to host temperature is a prerequisite for any pathogen capable of causing deep infection in humans. Our previous studies demonstrated that a Cryptococcus neoformans ccr4Δ mutant lacking the major deadenylase involved in regulated mRNA decay was defective in host temperature adaptation and therefore virulence. In this study, the ccr4Δ mutant was found to exhibit characteristics of chronic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Temperature
Share to Cryptococcus neoformans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum

Share to Gene Expression Regulation, Fungal

Share to Gene Knockout Techniques

Share to Microscopy, Fluorescence

Share to Stress, Physiological

Share to Unfolded Protein Response

Source

Open in PubMed Open full text

Identifiers

PMID: 21602483
DOI: 10.1128/EC.00006-11
PMCID: PMC3147416

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ccr4 promotes resolution of the endoplasmic reticulum stress response during host temperature adaptation in Cryptococcus neoformans.PMID 21602483Read ↗

Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogrammingSemantic proximity Read ↗

Rewiring of Signaling Networks Modulating Thermotolerance in the Human Pathogen Cryptococcus neoformansSemantic proximity Read ↗

Unique Evolution of the UPR Pathway with a Novel bZIP Transcription Factor, Hxl1, for Controlling Pathogenicity of Cryptococcus neoformansSemantic proximity Read ↗

Temperature-regulated transcription in the pathogenic fungus Cryptococcus neoformans.Semantic proximity Read ↗

Transcription factor Liv4 is required for growth and pathogenesis of Cryptococcus neoformans.Semantic proximity Read ↗

NMD-mediated control of Tor influences adaptation to nutrient and temperature conditions in <i>Cryptococcus neoformans</i>Semantic proximity Read ↗

Puf4 regulates both splicing and decay of HXL1 mRNA encoding the unfolded protein response transcription factor in Cryptococcus neoformans.Semantic proximity Read ↗

Cryptococcus neoformans requires the TVF1 gene for thermotolerance and virulenceSemantic proximity Read ↗

Trehalose-6-phosphate synthase promotes thermotolerance by governing glycolytic flux in <i>Cryptococcus deneoformans</i>Semantic proximity Read ↗

Translational Regulation Promotes Oxidative Stress Resistance in the Human Fungal Pathogen <i>Cryptococcus neoformans</i>Semantic proximity Read ↗

Gcn2 rescues reprogramming in the absence of Hog1/p38 signaling in <i>C. neoformans</i> during thermal stressSemantic proximity Read ↗

ZNF334 truncation mutation drives cold-induced autoinflammation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.