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Article

Unconventional Splicing of XBP-1 mRNA in the Unfolded Protein Response

2 Nov 2007

Abstract excerpt

Cytoplasmic splicing is one of the major regulatory mechanisms of the unfolded protein response (UPR). The molecular mechanism of cytoplasmic splicing is unique and completely different from that of conventional nuclear splicing. The mammalian substrate of cytoplasmic splicing is XBP1 pre-mRNA, which is converted to spliced mRNA in response to UPR, leading to the production of an active transcription factor...

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PMID: 17979529
DOI: 10.1089/ars.2007.1800

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