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Article

Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance.

Neuron - 1 Jul 1999

Hahm S, Mizuno T M, Wu T J, Wisor J P, Priest C A, Kozak C A, Boozer C N, Peng B, McEvoy R C, Good P, Kelley K A, Takahashi J S, Pintar J E, Roberts J L, Mobbs C V, Salton S R

Abstract excerpt

To determine the function of VGF, a secreted polypeptide that is synthesized by neurons, is abundant in the hypothalamus, and is regulated in the brain by electrical activity, injury, and the circadian clock, we generated knockout mice lacking Vgf. Homozygous mutants are small, hypermetabolic, hy...

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Source

Identifiers

PMID: 10433265
DOI: 10.1016/s0896-6273(00)80806-5

Genes

VGF
AGRP
NPY
POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10433265-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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