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Article

Hepatocyte nuclear factor 4 alpha polymorphisms and the metabolic syndrome in French-Canadian youth.

PloS one - 1 Jan 2015

Marcil Valérie, Amre Devendra, Seidman Ernest G, Boudreau François, Gendron Fernand P, Ménard Daniel, Beaulieu Jean François, Sinnett Daniel, Lambert Marie, Levy Emile

Abstract excerpt

OBJECTIVES: Hepatocyte nuclear factor 4 alpha (HNF4α) is a transcription factor involved in the regulation of serum glucose and lipid levels. Several HNF4A gene variants have been associated with the risk of developing type 2 diabetes mellitus. However, no study has yet explored its association with insulin resistance and the cardiometabolic risk in children. We aimed to investigate the relationship between HNF4A...

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Identifiers

PMID: 25671620
DOI: 10.1371/journal.pone.0117238
PMCID: PMC4325000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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