Article
Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population.
JAMA - 11 Jun 2014
Estrada Karol, Aukrust Ingvild, Bjørkhaug Lise, Burtt Noël P, Mercader Josep M, García-Ortiz Humberto, Huerta-Chagoya Alicia, Moreno-Macías Hortensia, Walford Geoffrey, Flannick Jason, Williams Amy L, Gómez-Vázquez María J, Fernandez-Lopez Juan C, Martínez-Hernández Angélica, Jiménez-Morales Silvia, Centeno-Cruz Federico, Mendoza-Caamal Elvia, Revilla-Monsalve Cristina, Islas-Andrade Sergio, Córdova Emilio J, Soberón Xavier, González-Villalpando María E, Henderson E, Wilkens Lynne R, Le Marchand Loic, Arellano-Campos Olimpia, Ordóñez-Sánchez Maria L, Rodríguez-Torres Maribel, Rodríguez-Guillén Rosario, Riba Laura, Najmi Laeya A, Jacobs Suzanne B R, Fennell Timothy, Gabriel Stacey, Fontanillas Pierre, Hanis Craig L, Lehman Donna M, Jenkinson Christopher P, Abboud Hanna E, Bell Graeme I, Cortes Maria L, Boehnke Michael, González-Villalpando Clicerio, Orozco Lorena, Haiman Christopher A, Tusié-Luna Teresa, Aguilar-Salinas Carlos A, Altshuler David, Njølstad Pål R, Florez Jose C, MacArthur Daniel G
Abstract excerpt
IMPORTANCE: Latino populations have one of the highest prevalences of type 2 diabetes worldwide. OBJECTIVES: To investigate the association between rare protein-coding genetic variants and prevalence of type 2 diabetes in a large Latino population and to explore potential molecular and physiological mechanisms for the observed relationships. DESIGN, SETTING, AND PARTICIPANTS: Whole-exome sequencing was performed...
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