Article
Variants in hepatocyte nuclear factor 4alpha gene promoter region and type 2 diabetes risk in Chinese.
Experimental biology and medicine (Maywood, N.J.) - 1 Jul 2010
Chen Zhuo, Zhang Di, Liu Yun, Zhou Daizhan, Zhao Teng, Yang Yifeng, He Lin, Xu He
Abstract excerpt
As a key regulator of insulin secretion and metabolism of glucose, cholesterol and fatty acid, hepatocyte nuclear factor 4alpha (HNF4A) was suggested as a candidate gene for type 2 diabetes (T2D); however, no association study between HNF4A and T2D in the Chinese population has been conducted before. To address this issue, we evaluated the impact of the HNF4A variants (rs1884614 and rs2425637) on T2D and...
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