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Article

The role of HNF4A variants in the risk of type 2 diabetes.

Current diabetes reports - 1 Apr 2005

Mohlke Karen L, Boehnke Michael

Abstract excerpt

Genes influence susceptibility to type 2 diabetes mellitus (T2DM), and both positional cloning and candidate gene approaches have been used to identify these genes. Linkage analysis has generated evidence for T2DM-predisposing variants on chromosome 20q in studies of Caucasians, Asians, and Africans, and fine-mapping recently identified a likely susceptibility gene, hepatocyte nuclear factor 4-alpha (HNF4A). Rare...

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Source

Identifiers

PMID: 15794920
DOI: 10.1007/s11892-005-0043-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The role of HNF4A variants in the risk of type 2 diabetes.PMID 15794920Read ↗

HNF4A genetic variants: role in diabetes.Semantic proximity Read ↗

Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish population.Semantic proximity Read ↗

Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.Semantic proximity Read ↗

A role for coding functional variants in HNF4A in type 2 diabetes susceptibility.Semantic proximity Read ↗

Influence of hepatocyte nuclear factor 4alpha (HNF4alpha) gene variants on the risk of type 2 diabetes: a meta-analysis in 49,577 individuals.Semantic proximity Read ↗

Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes.Semantic proximity Read ↗

Genetic analysis of HNF4A polymorphisms in Caucasian-American type 2 diabetes.Semantic proximity Read ↗

Functional Investigations of HNF1A Identify Rare Variants as Risk Factors for Type 2 Diabetes in the General Population.Semantic proximity Read ↗

Variants in hepatocyte nuclear factor 4alpha gene promoter region and type 2 diabetes risk in Chinese.Semantic proximity Read ↗

Studies in 3,523 Norwegians and meta-analysis in 11,571 subjects indicate that variants in the hepatocyte nuclear factor 4 alpha (HNF4A) P2 region are associated with type 2 diabetes in Scandinavians.Semantic proximity Read ↗

Variants in hepatocyte nuclear factor 4alpha are modestly associated with type 2 diabetes in Pima Indians.Semantic proximity Read ↗

Hepatocyte nuclear factor-4alpha P2 promoter haplotypes are associated with type 2 diabetes in the Japanese population.Semantic proximity Read ↗

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