Article
Association between genetic variants in the HNF4A gene and childhood-onset Crohn's disease.
Genes and immunity - 1 Oct 2012
Marcil V, Sinnett D, Seidman E, Boudreau F, Gendron F-P, Beaulieu J-F, Menard D, Lambert M, Bitton A, Sanchez R, Amre D, Levy E
Abstract excerpt
Hepatocyte nuclear 4 alpha (HNF4α), involved in glucose and lipid metabolism, has been linked to intestinal inflammation and abnormal mucosal permeability. Moreover, in a genome-wide association study, the HNF4A locus has been associated with ulcerative colitis. The objective of our study was to evaluate the association between HNF4α genetic variants and Crohn's disease (CD) in two distinct Canadian pediatric...
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