Genetic interaction mapping informs integrative structure determination of protein complexes.

doi:10.1126/science.aaz4910

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Article

Genetic interaction mapping informs integrative structure determination of protein complexes.

Science (New York, N.Y.) - 11 Dec 2020

Braberg Hannes, Echeverria Ignacia, Bohn Stefan, Cimermancic Peter, Shiver Anthony, Alexander Richard, Xu Jiewei, Shales Michael, Dronamraju Raghuvar, Jiang Shuangying, Dwivedi Gajendradhar, Bogdanoff Derek, Chaung Kaitlin K, Hüttenhain Ruth, Wang Shuyi, Mavor David, Pellarin Riccardo, Schneidman Dina, Bader Joel S, Fraser James S, Morris John, Haber James E, Strahl Brian D, Gross Carol A, Dai Junbiao, Boeke Jef D, Sali Andrej, Krogan Nevan J

Abstract excerpt

Determining structures of protein complexes is crucial for understanding cellular functions. Here, we describe an integrative structure determination approach that relies on in vivo measurements of genetic interactions. We construct phenotypic profiles for point mutations crossed against gene deletions or exposed to environmental perturbations, followed by converting similarities between two profiles into an...

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PMID: 33303586
DOI: 10.1126/science.aaz4910
PMCID: PMC7946025

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