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Article

ABC transporters: unvalidated therapeutic targets in cancer and the CNS.

Anti-cancer agents in medicinal chemistry - 1 Oct 2010

Robey Robert W, Massey Paul R, Amiri-Kordestani Laleh, Bates Susan E

Abstract excerpt

The discovery of the multidrug transporter P-glycoprotein (Pgp) over 35 years ago in drug resistant cells prompted several decades of work attempting to overcome drug resistance by inhibition of drug efflux. Despite convincing laboratory data showing that drug transport can be inhibited in vitro, efforts to translate this discovery to the clinic have not succeeded. Since overexpression of Pgp and related...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21189132
DOI: 10.2174/187152010794473957
PMCID: PMC3119022

Genes

ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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