Article
ABC transporters: unvalidated therapeutic targets in cancer and the CNS.
Anti-cancer agents in medicinal chemistry - 1 Oct 2010
Robey Robert W, Massey Paul R, Amiri-Kordestani Laleh, Bates Susan E
Abstract excerpt
The discovery of the multidrug transporter P-glycoprotein (Pgp) over 35 years ago in drug resistant cells prompted several decades of work attempting to overcome drug resistance by inhibition of drug efflux. Despite convincing laboratory data showing that drug transport can be inhibited in vitro, efforts to translate this discovery to the clinic have not succeeded. Since overexpression of Pgp and related...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- ATP-Binding Cassette Transporters
- Animals
- Antineoplastic Agents
- Blood-Brain Barrier
- Central Nervous System
- Clinical Trials as Topic
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Humans