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Article

Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition.

Nature communications - 11 Feb 2015

Goldman Aaron, Majumder Biswanath, Dhawan Andrew, Ravi Sudharshan, Goldman David, Kohandel Mohammad, Majumder Pradip K, Sengupta Shiladitya

Abstract excerpt

Understanding the emerging models of adaptive resistance is key to overcoming cancer chemotherapy failure. Using human breast cancer explants, in vitro cell lines, mouse in vivo studies and mathematical modelling, here we show that exposure to a taxane induces phenotypic cell state transition towards a favoured transient CD44(Hi)CD24(Hi) chemotherapy-tolerant state. This state is associated with a clustering of...

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Identifiers

PMID: 25669750
DOI: 10.1038/ncomms7139
PMCID: PMC4339891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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