Article

Regulatory network and spatial modeling reveal cooperative mechanisms of resistance and immune escape in ER <sub>+</sub> breast cancer

2025-10-02

Abstract excerpt

Despite significant progress, the treatment of estrogen receptorpositive (ER+) breast cancer remains clinically challenging due to reversible drug resistance and immune evasion. Drug resistance often arises as cells undergo a dynamic epithelial-to-mesenchymal transition (EMT), while elevated PD-L1 levels contribute to immune escape. While these phenotypic features can variably co-occur, the impact of co-occurrence...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d8bd4020-2560-5bf2-ba31-882f908eff87
DOI: 10.1101/2025.09.30.679692

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Regulatory network and spatial modeling reveal cooperative mechanisms of resistance and immune escape in ER <sub>+</sub> breast cancerDOI 10.1101/2025.09.30.679692Read

A mechanistic model captures the emergence and implications of non-genetic heterogeneity and reversible drug resistance in ER+ breast cancer cellsSemantic proximity Read

From tumor microenvironment to immuno-therapeutic outcomes for solid tumors: A systems theoretic approachSemantic proximity Read

Spatial Agent-Based Modeling and Interpretable Machine Learning Predict Combination Therapy Response in HER2-Heterogeneous Breast CancerSemantic proximity Read

Immunosuppressive traits of the hybrid epithelial/mesenchymal phenotypeSemantic proximity Read

Robustness in phenotypic plasticity and heterogeneity patterns enabled by EMT networks.Semantic proximity Read

Immunosuppressive Traits of the Hybrid Epithelial/Mesenchymal Phenotype.Semantic proximity Read

Serial Spatial Transcriptomics Reveal Divergent Routes to Therapy Resistance in Metastatic Breast CancerSemantic proximity Read

Bidirectional coupling among EMT, AXL-RB1 signaling and lineage switch drives resistance to osimertinib and worse clinical outcomes in NSCLCSemantic proximity Read

Endocrine therapy-specific lineage and partial epithelial-mesenchymal reprogramming defines divergent resistant cell-states in ER+ breast cancerSemantic proximity Read

A systems-level analysis of the mutually antagonistic roles of RKIP and BACH1 in dynamics of cancer cell plasticitySemantic proximity Read

Convergent evolution of resistance pathways during early stage breast cancer treatment with combination cell cycle (CDK) and endocrine inhibitorsSemantic proximity Read

Phenotypic plasticity and competition shape therapy sequencing in HER2+/HER2- breast cancer: A mathematical framework.Semantic proximity Read